Toll Free 1-800-300-2919

Request Your Free Mesothelioma Book

  • Check here if you or someone you know has mesothelioma:
  • Has a biopsy been performed?
  • What is the current treatment plan?

Real Answers For Those With Mesothelioma

  • Get the Latest Treatment Options
  • Connect with Top Doctors and Specialists
  • Learn About Financial and Legal Assistance
  • See the Latest Information for Veterans

packet of books and informational pamphlets on Mesothelioma

NCI, Selecta Launch Clinical Trial for New Pleural, Peritoneal Mesothelioma Treatment

Selecta Biosciences and the National Cancer Institute (NCI) have teamed up for a Phase 1 Clinical Trail that will evaluate the safety and tolerability of a promising new drug combination known as SEL-403. The combination consists of two drugs—LMB-100 and SVP-Rapamycin. “SVP-Rapamycin is Selecta’s proprietary, clinical-stage anti-drug antibody (ADA) prevention and immune tolerance technology,” reports Global Newswire. LMB-100 is a “recombinant immunotoxin that targets mesothelin.”

Mesothelin is a protein expressed in nearly all mesotheliomas and pancreatic adenocarcinomas, and a high percentage of other malignancies, including breast, lung, and ovarian cancers.

The trial is enrolling patients with malignant pleural or peritoneal mesothelioma who have undergone at least one regimen of chemotherapy. Patients will receive up to four treatment cycles, with each treatment cycle consisting of an initial dose of SEL-403 on day one, followed by two doses of LMB-100 alone on days three and five. The study expects to enroll up to 18 patients, and the first patient received the combination therapy in March.

“Mesothelioma remains one of the deadliest and most challenging-to-treat forms of cancer,” said Raffit Hassan, Principal Investigator on the clinical trial. “Recombinant immunotoxins hold the potential to induce marked anti-tumor activity if anti-drug antibodies are prevented and sufficient cycles of therapy can be administered. We are pleased to get this clinical investigation underway to determine if patients may indeed benefit from a combination therapy consisting of LMB-100 and SVP-Rapamycin.”


About Clinical Trials

According to the National Heart, Lung, and Blood Institute (NHLBI), clinical trials are research studies that explore whether a medical strategy, treatment, or device is safe and effective for humans. These studies also may show which medical approaches work best for certain groups of people and illnesses. Clinical trials produce the best data available for health care decision-making. A clinical trial may find that a new strategy, treatment, or device improves patient outcomes, offers no benefit, or causes unexpected harm. All of these results are important because they advance medical knowledge and help improve patient care.

If you have been diagnosed with mesothelioma, talk to your doctor about participating in a clinical trial. A new or experimental therapy could be effective in treating your specific type of mesothelioma. Talk to your doctor about clinical trials today.



"About Clinical Trials." National Heart, Lung, and Blood Institute (NHLBI). U.S. Department of Health and Human Services, 2018. Web. 10 Apr. 2018.

"Selecta Biosciences Announces First Patient Dosed in Phase 1 Trial of SVP-Rapamycin and LMB-100 Combination Therapy in Mesothelioma." GlobeNewswire News Room. "GlobeNewswire", 12 Mar. 2018. Web. 10 Apr. 2018.